1P-LSD 150mcg Blotters (Minion Design)

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1-Propionyl-d-lysergic acid diethylamide (1P-LSD) is a novel psychedelic substance belonging to the lysergamide class. It shares structural similarities with LSD and other emerging lysergamides such as 1cP-LSD, 1B-LSD, and 1V-LSD. The substance is believed to exert its effects by stimulating serotonin receptors in the brain, although the exact mechanism remains unclear.

History and Market Presence

Since its introduction to the online market as a research chemical in 2015, 1P-LSD has gained attention as a legal alternative to LSD. Its original synthesis date is unknown, and it lacks a documented presence in research literature prior to its emergence. Alongside other novel lysergamides like ALD-52, ETH-LAD, and AL-LAD, it has been marketed for its psychoactive properties.

Subjective Effects

Users of 1P-LSD report a range of subjective effects, including geometric visual hallucinations, time distortion, enhanced introspection, conceptual thinking, euphoria, and ego loss. Anecdotal evidence suggests that the effects closely resemble those of LSD, leading to the hypothesis that 1P-LSD may act as a prodrug for LSD. This theory is supported by studies indicating that 1P-LSD is metabolized into LSD in animal models.

Chemistry of 1P-LSD

1P-LSD is classified as a semisynthetic compound within the lysergamide family. Its name derives from the propionyl group attached to the nitrogen of the polycyclic indole structure of LSD. The propionyl group consists of a carbonyl chain (CH3CH2CO-) linked to an amino group. In contrast, ALD-52, a related compound, features an acetyl group at the same nitrogen position.

Pharmacological Profile

Given its structural resemblance to LSD, 1P-LSD is likely a partial agonist at the 5-HT2A receptor, which is thought to mediate its psychedelic effects. Additionally, it may interact with various monoamine receptors, including those for dopamine and norepinephrine, although empirical data to confirm these interactions is currently lacking.

Future Research Directions

Research is ongoing to explore the pharmacological properties of 1P-LSD, particularly its potential as a prodrug for LSD. Initial studies indicate that while 1P-LSD exhibits only 38% of LSD's potency in mice, LSD can be detected when 1P-LSD is incubated in human serum. Further investigations aim to compare the affinity and selectivity of both compounds at 5-HT receptors and to clarify whether 1P-LSD is hydrolyzed to LSD in vivo.

1P-LSD 150mcg Blotters (Minion Design) is for research use only and not intended for human consumption!

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1P-LSD 150mcg Blotters (Minion Design) stock last updated at: April 2025