1V-LSD 150mcg Blotters

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1-Valeroyl-d-lysergic acid diethylamide, commonly referred to as 1V-LSD or Valerie, is a novel psychedelic substance belonging to the lysergamide class. This compound is closely related to both LSD and 1P-LSD, and user reports suggest that it produces effects that are nearly identical to those of its counterparts. Although the pharmacology of 1V-LSD is not fully understood, it is presumed to function similarly to LSD, interacting with serotonin, dopamine, and norepinephrine receptors in the brain.

History and Synthesis

1V-LSD is a research chemical that was first synthesized around June or July of 2021. Its introduction coincided with the announcement of the German NpSG ban on 1cP-LSD, marking a significant moment in the landscape of novel psychoactive substances.

Effects and User Experience

User experiences indicate that the subjective effects of 1V-LSD closely mirror those of 1P-LSD and LSD. It is theorized that 1V-LSD may act as a prodrug for LSD, with its chemical structure predicting a similar effects profile, primarily varying in absorption rate and duration. Users report experiencing geometric visual hallucinations, time distortion, enhanced introspection, and ego loss. The favorable tolerability and classical psychedelic effects have contributed to its popularity among users of novel psychoactive substances, who often use it interchangeably with LSD.

Chemistry

1V-LSD is classified as a member of the lysergamide family, characterized by its structural similarity to LSD. The compound is named for the valeryl group attached to the nitrogen of the polycyclic indole structure of LSD. The tetracyclic ergoline structure is a hallmark of ergot alkaloids, and 1V-LSD features an additional N1-valeryl group compared to LSD. Modifications at the N1 position are common in the ergoline system, as the indole nitrogen is readily accessible for various chemical reactions.

Pharmacology

Given its structural resemblance to LSD, 1V-LSD is likely to act as a partial agonist at the 5-HT2A receptor, with its psychedelic effects primarily attributed to its activity at these receptors throughout the brain. Additionally, it may exhibit binding activity at various monoamine receptors, including those for dopamine and norepinephrine, although current data to substantiate these claims is lacking. It has been suggested that 1V-LSD, along with its acyl homologs like 1P-LSD or ALD-52, may be converted to LSD in the body through the elimination of valeric acid, as indicated by studies involving human blood serum.

Subjective Effects

Anecdotal evidence from users suggests that the subjective effects of 1V-LSD and LSD are nearly indistinguishable. In comparison to other psychedelics such as psilocybin, LSA, and ayahuasca, 1V-LSD is noted for being significantly more stimulating and fast-paced in terms of its physical and cognitive effects.

Chemical Nomenclature

Common names: 1V-LSD
Substitutive name: 1-Valeryl-d-lysergic acid diethylamide
Psychoactive class: Psychedelic
Chemical class: Lysergamide

Dosage

Threshold	Light	Common	Strong	Heavy
15 µg	25 - 75 µg	75 - 150 µg	150 - 300 µg	300 µg +

Duration

Total Duration	Onset	Come Up	Peak	Offset	After Effects
8 - 12 hours	20 - 60 minutes	45 - 120 minutes	3 - 5 hours	3 - 5 hours	6 - 24 hours

1V-LSD 150mcg Blotters is for research use only and not intended for human consumption!

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1V-LSD 150mcg Blotters stock last updated at: April 2025