2-FA (2-Fluoroamphetamine) Powder

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2-Fluoroamphetamine (2-FA) is a novel stimulant belonging to the amphetamine class. As a structural analog of amphetamine, it is believed to operate through a similar mechanism, facilitating the release of dopamine and norepinephrine in the brain.

Emergence in the Research Chemical Market

2-FA is part of a broader category of amphetamine analogs that emerged in the online research chemical market during the 2010s. Other compounds in this series include 2-FMA, 3-FA, 3-FEA, and 4-FA. These substances are known to produce a variety of stimulating and euphoric effects, often serving as research chemical alternatives to traditional street stimulants and entactogens. Among these, 2-FA is frequently noted for its amphetamine-like subjective effects, often drawing comparisons to the d-isomer of amphetamine, known as dexedrine.

Administration and User Experience

Typically, 2-FA is consumed orally. Although it can also be taken through insufflation or vaporization, users have reported these methods to be particularly unpleasant compared to its parent compound. Some individuals have claimed that 2-FA can serve as an effective alternative to prescription stimulants for managing ADHD symptoms. However, there is limited knowledge regarding the potential toxicological effects associated with its long-term use as a substitute for prescribed medications.

Chemical Structure

2-FA, or 2-Fluoroamphetamine, is a synthetic compound within the amphetamine family. The amphetamine class is characterized by a phenethylamine core, which consists of a phenyl ring connected to an amino (NH2) group via an ethyl chain, with an additional methyl substitution at Rα. Unlike its close analogue 2-FMA, 2-FA lacks a methyl group attached to the terminal amine RN of the amphetamine core, making it structurally and functionally similar to amphetamine. Specifically, 2-FA is the 2-position fluorinated variant of amphetamine.

Pharmacological Insights

While 2-FA has not undergone formal studies comparable to traditional amphetamines, it is reasonable to infer that, like other substituted amphetamines with similar modifications, it likely functions primarily as a dopamine and norepinephrine releasing agent. This mechanism involves binding to and partially inhibiting the transporter proteins responsible for clearing these monoamines from the synaptic cleft, leading to increased levels of norepinephrine and dopamine in the brain. The result is a range of stimulating, motivating, and euphoric effects.

Subjective Effects and User Reports

Compared to other substituted amphetamines, 2-FA is often reported to have fewer side effects, such as nausea, elevated blood pressure, anxiety, and uncomfortable comedowns. Users describe it as a functional and effective psychoactive substance for enhancing productivity, akin to dextroamphetamine. However, at higher doses, its effects may shift from productivity enhancement to recreational use, characterized by distracting euphoria and overstimulation. Notably, some users suggest that 2-FA has a "ceiling dose," which may lower its potential for abuse compared to methamphetamine, although this claim has yet to be scientifically validated.

2-FA (2-Fluoroamphetamine) Powder is for research use only and not intended for human consumption!

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2-FA (2-Fluoroamphetamine) Powder stock last updated at: April 2025