2C-D 12mg Pellets

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2,5-Dimethoxy-4-methylphenethylamine, commonly known as 2C-M, LE-25, and more frequently referred to as 2C-D, is a synthetic psychedelic belonging to the phenethylamine chemical class. It produces short-lived psychedelic effects when administered. Its sensory and cognitive effects profile has been described as the most similar to that of mescaline among the 2C-x family, although it has a significantly shorter duration. The synthesis of 2C-D was first published in 1970 by a team from the Texas Research Institute of Mental Sciences, with initial trials conducted by Alexander Shulgin at sub-threshold doses in 1964.

Effects and Anecdotal Reports

Anecdotal reports suggest that 2C-D is calmer, easier to handle, and more comfortable on the body compared to other closely related psychedelic phenethylamines. While it is not especially visual or physically euphoric at common doses, users report that it is very lucid, analytical, and unimpaired in its headspace—a quality that persists even as the dose increases. Lower doses of 2C-D (generally 10 mg or less) have been explored for potential nootropic effects, albeit with mixed results. Today, 2C-D is used both recreationally and as an entheogen.

History and Culture

The synthesis of 2C-D was first published in 1970, but initial trials by Alexander Shulgin were conducted in 1964. Further investigations at higher doses were carried out by Shulgin and his colleagues between 1974 and 1978. The name '2C-D' derives from its chemical structure, as it is the 2-Carbon analogue of DOM. Shulgin referred to 2C-D as a “pharmacological tofu,” suggesting that it can extend or enhance the effects of other substances without significantly altering the experience, similar to how tofu absorbs flavors in cooking. While some view this as evidence that 2C-D is relatively uninteresting as a standalone psychedelic, others argue that it is a versatile and fully-fledged psychedelic in its own right. Despite its potential as a functional psychostimulant and successful studies investigating its use in psychotherapy in Germany, 2C-D has not achieved widespread use. This is often attributed to the previously limited diversity of substances available, a dynamic that has changed significantly with the advent of the internet, allowing for broader choices among psychedelic phenethylamine explorers. Consequently, 2C-D tends to be harder to find and notably more expensive by weight.

Chemistry

2C-D, or 2,5-dimethoxy-4-methylphenethylamine, is a substituted phenethylamine characterized by a phenyl ring connected to an amino (NH2) group via an ethyl chain. It contains methoxy functional groups (CH3O-) attached to carbons R2 and R5, as well as a methyl group attached to carbon R4 of the phenyl ring. 2C-D belongs to the 2C family of phenethylamines, which are defined by the presence of methoxy groups at the 2 and 5 positions of the benzene ring.

Pharmacology

The psychedelic effects of 2C-D are believed to arise from its efficacy at the 5-HT2A receptor as a partial agonist. However, the specific mechanisms of these interactions and how they contribute to the psychedelic experience remain elusive.

Subjective Effects

The headspace experienced with 2C-D is often described as lucid, insightful, and relatively normal in thought processes, even at moderate to high doses. This feeling of unaltered consciousness may be unsatisfying for users seeking an intense experience, as the headspace tends to be stable and sometimes uninteresting for those new to hallucinogenic experiences.

2C-D 12mg Pellets is for research use only and not intended for human consumption!

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2C-D 12mg Pellets stock last updated at: April 2025