JWH-210 Powder

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JWH-210 is an analgesic compound belonging to the naphthoylindole family, recognized for its potent activity as a cannabinoid agonist at both the CB1 and CB2 receptors. With Ki values of 0.46 nM at CB1 and 0.69 nM at CB2, JWH-210 stands out as one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series. Its binding affinity at CB1 is notably higher (i.e., lower Ki) than that of its homologues, including JWH-122 (CB1 Ki 0.69 nM) and JWH-182 (CB1 Ki 0.65 nM), as well as the 4-methoxy compound JWH-081 (CB1 Ki 1.2 nM). This compound was discovered by and named after John W. Huffman.

Identifiers

• IUPAC Name: 4-Ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone
• CAS Number: 824959-81-1 (JWH-210), 824960-02-3 (JWH-182)
• PubChem CID: 45270396
• ChemSpider: 24617616
• UNII: R18JYO04PY
• CompTox Dashboard (EPA): DTXSID301010019
• ECHA InfoCard: 100.233.380

Chemical and Physical Data

• Formula: C26H27NO
• Molar Mass: 369.508 g·mol−1
• SMILES: c4cccc2c4c(CC)ccc2C(=O)c(c3)c1ccccc1n3CCCCC
• InChI Code: InChI=1S/C26H27NO/c1-3-5-10-17-27-18-24(22-13-8-9-14-25(22)27)26(28)23-16-15-19(4-2)20-11-6-7-12-21(20)23/h6-9,11-16,18H,3-5,10,17H2,1-2H3
• InChI Key: LACIUQLUNACUKC-UHFFFAOYSA-N

Conclusion

JWH-210 is a significant compound in cannabinoid research, demonstrating high potency and affinity for cannabinoid receptors. Its unique properties and potential therapeutic applications make it a subject of interest for further studies. As research continues, JWH-210 may contribute to the understanding and development of cannabinoid-based therapies.

JWH-210 Powder is for research use only and not intended for human consumption!

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JWH-210 Powder stock last updated at: April 2025