LSZ 200mcg Blotters

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Lysergic acid 2,4-dimethylazetidide (also known as λ, Lambda, and LSZ) is a synthetic psychedelic of the lysergamide chemical class which produces LSD-like psychedelic effects when administered.

In the 2000s, a team led by David E. Nichols at Purdue University set out to develop a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor. LSZ has little to no history of human usage prior to 2012 when it appeared on some research chemical markets. LSZ later gained international popularity and distributed on blotter paper or in liquid solution under names such as "Diazedine" and "λ" (or "Lambda").

Chemistry

LSZ, or d-lysergic acid 2,4-dimethylazetidide, is a semi-synthetic alkaloid of the lysergamide family. It contains a core structure of lysergic acid with an amine functional group bound to RN of the chemical structure. This core polycyclic structure is an indole derivative, and has tryptamine and phenethylamine groups embedded within it. The structure contains a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). At carbon 8 of the quinoline, an amide group is bound. Additionally, the substitutions of the terminal nitrogen atom of the amide group form a 2,4-dimethylazetidide group. LSZ is additionally substituted at carbon 6 with a methyl group. There are three possible stereoisomers around the azetidine ring, with the (S,S)-(+) isomer being the most active. It is slightly more potent than LSD itself in drug discrimination tests using trained rats.

Pharmacology

LSZ likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from LSZ's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Chemical Nomenclature

• Common names: LSZ, LA-SS-Az, Diazedine, Lambda
• Substitutive name: Lysergic acid 2,4-dimethylazetidide
• Systematic name: (8β)-8-{[(2S,4S)-2,4-Dimethylazetidin-1-yl]carbonyl}-6-methyl-9,10-didehydroergoline

Class Membership

• Psychoactive class: Psychedelic
• Chemical class: Lysergamide

Dosage

• Threshold: 50 µg
• Light: 100 - 150 µg
• Common: 150 - 300 µg
• Strong: 300 - 400 µg
• Heavy: 400 µg +

Duration

• Total: 6 - 10 hours
• Onset: 20 - 60 minutes
• Come up: 30 - 60 minutes
• Offset: 2 - 3 hours
• After effects: 6 - 24 hours

LSZ 200mcg Blotters is for research use only and not intended for human consumption!

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LSZ 200mcg Blotters stock last updated at: April 2025