Methallylescaline Fumarate Powder

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4-Methallyloxy-3,5-dimethoxyphenethylamine, commonly known as methallylescaline or MAL, is a synthetic psychedelic substance belonging to the phenethylamine chemical class. It is reported to produce hallucinogenic and stimulant effects that are comparable to other mescaline analogs, such as allylescaline, proscaline, and escaline, when administered.

Effects and Dosage

The effects of methallylescaline were first documented by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. He lists the dosage range as 40mg to 60mg when taken orally, with a duration of action reported to be between 8 to 12 hours. Anecdotal reports suggest that methallylescaline bears the closest resemblance to mescaline, although higher dosages may lead to a significant body load.

Chemistry

Methallylescaline, or 4-methallyloxy-3,5-dimethoxyphenethylamine, is a substituted phenethylamine characterized by a phenyl ring connected to an amino (NH2) group via an ethyl chain. It features two methoxy functional groups (CH3O-) attached to carbons R3 and R5 of the phenyl ring. The compound is further substituted at R4 with a methallyloxy chain, which consists of a three-carbon chain with a methyl-substituted allyl group that has a double bond on the terminal carbon. This chain is linked to the phenyl ring at R4 through an ether (oxygen) bridge.

Pharmacology

Methallylescaline is believed to act as a 5-HT2A partial agonist. The psychedelic effects are thought to arise from its efficacy at the 5-HT2A receptors. However, the specific mechanisms of these interactions and how they contribute to the psychedelic experience remain poorly understood.

Methallylescaline Fumarate Powder is for research use only and not intended for human consumption!

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Methallylescaline Fumarate Powder stock last updated at: April 2025