Norflurazepam 5mg Pellets

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Norfludiazepam is a designer benzodiazepine that shares structural similarities with the drug diazepam. It is the active metabolite of flurazepam and fludiazepam but has a longer half-life than flurazepam. Producers and researchers often use it to make midazolam — either as an intermediate or as the starting material itself.

Neither the 1961 Single Convention on Narcotic Drugs nor the 1971 United Nations Convention on Psychotropic Substances regulates norfludiazepam.

First identified in Stockholm, Sweden, by Swedish customs in 2016, norflurazepam appeared on the scene as a white powder. Since 2016, the reputation surrounding it has marketed it as a designer drug.

Norflurazepam Specs

• Common Dosage: 5-10 mg
• PubChem ID: 4540
• CAS#: 2886-65-9
• IUPAC Name: 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
• Other Names: Norfludiazepam, N-Desalkylflurazepam, Norflutoprazepam, Descarbethoxyloflazepate

Metabolism

Norflurazepam is largely metabolized into inactive metabolites by the cytochrome P450 enzymes, including the CYP3A4 enzyme that takes place in the liver.

Duration of Effects

Intermediate-acting (10-16 hours). Onset is within 45-120 minutes, and after-effects may last for 1-12 hours.

What is the Dose of Norflurazepam?

A light dose of norflurazepam is 2 to 5 mg, and the common dose is 5 to 10 mg. Most people consider 10 to 20 mg and over to be a strong dose.

How Does Norflurazepam Work?

The γ-aminobutyric acid type A (GABA-A) receptor — expressed on both the presynaptic and postsynaptic terminal of neurons — is the main target of benzodiazepines.

These GABA channels primarily function through ligand-gated ion channels. The membrane becomes hyperpolarized when these ligand-gated ion channels open, inhibiting neurotransmission. GABA is one of the body’s primary inhibitory neurotransmitters.

The GABA receptor complex is made up of five different protein subunits that are broadly distributed throughout the nervous system; 2 subunits, 2 subunits, and 1 subunit constitute it. Additionally, every one of these subunits comes in several isoforms.

Between the α and γ subunits is the location of benzodiazepines’ binding site. The GABA-A receptors transform chemical inputs into electrical signals in a fraction of a millisecond. Due to this interaction, the GABA-A receptor undergoes a conformational change, and subsequent responses follow.

Since even small variations in just one subtype may radically change properties like potency, various benzodiazepines have diverse effects. This means that even molecules with a similar structural makeup might vary significantly. Norflurazepam binds unselectively to the numerous benzodiazepine receptor subtypes.

GABA-A receptors quickly inhibit the whole basal ganglia network. Norflurazepam is a benzodiazepine capable of various physical and mental effects by binding to various subtypes of GABA-A.

Norflurazepam 5mg Pellets is for research use only and not intended for human consumption!

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Norflurazepam 5mg Pellets stock last updated at: April 2025