PRO-LAD 200mcg Blotters

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N-Propylnorlysergic acid N,N-diethylamide (also known as 6-Propyl-6-nor-lysergic acid diethylamide, N-PropylnorLSD, or simply PRO-LAD) is a novel psychedelic substance of the lysergamide class. It is a structural analog of LSD and is part of a series of LSD analogs which includes AL-LAD and ETH-LAD.

PRO-LAD was first investigated by Andrew J. Hoffman and David E. Nichols in 1984 as part of a series of LSD analogs. It was later described as an analog of LSD by Alexander Shulgin in the book TiHKAL ("Tryptamines I Have Known and Loved"), in which one report remarks that it is "good for humor, even excellent... very good for clear thinking, although not cosmic-type particularly." It has been sold on the online research chemical market alongside lysergamides like 1P-LSD and AL-LAD as a legal alternative to LSD.

Subjective effects are similar to LSD and include open and closed-eye visuals, time distortion, enhanced introspection, ego loss, and euphoria. It has been reported to be around as potent as LSD itself, with an active dose reported at between 100 and 200 micrograms.

Chemistry

PRO-LAD, or 6-propyl-6-nor-lysergic acid diethylamide, is a semisynthetic alkaloid of the lysergamide family. PRO-LAD is a chiral compound with two stereocenters at R5 and R8. PRO-LAD, also called (+)-D-PRO-LAD, has an absolute configuration of (5R, 8R). It is a structural analog of lysergic acid, with an N,N-diethylamide functional group bound to RN of the chemical structure. This core polycyclic structure is an ergoline derivative, and has overlapping tryptamine and phenethylamine groups embedded within it (although it is principally classed as a tryptamine).

It differs from LSD by the addition of two carbons to the methyl group at R6 of the structure to form a propyl chain. PRO-LAD's structure contains a bicyclic hexahydroindole fused to a bicyclic quinoline group (nor-lysergic acid). Unlike LSD, PRO-LAD does not contain a methyl group substituted at R6 of its nor-lysergic acid skeleton, this is represented by the nor- prefix. Instead, PRO-LAD is substituted at R6 with a propyl group. At carbon 8 of the quinoline, a N,N-diethyl carboxamide is bound.

PRO-LAD is a derivative of LSD, differing by the addition of two carbons to the methyl group at R6 of the structure to form a propyl chain. PRO-LAD is also homologous to ETH-LAD, which contains an ethyl substitution at R6 instead of a propyl chain. PRO-LAD is a chiral compound with two stereocenters at R5 and R8. It is also sometimes called (+)-D-PRO-LAD, as an absolute configuration of (5R, 8R).

Pharmacology

PRO-LAD likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from PRO-LAD's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain an object of scientific elucidation.

As a derivative of LSD, the pharmacodynamic and pharmacokinetic properties of PRO-LAD are similar to those of LSD. However, they are not exactly the same. The addition of two carbons to the methyl group at R6, and the resulting propyl chain may lead to PRO-LAD being absorbed at a slower rate and therefore a differing initial onset and a peak effect. This could be the reason for the higher threshold and common dosages.

Chemical Nomenclature

• Common names: PRO-LAD
• Substitutive name: 6-Propyl -6-nor-lysergic acid diethylamide
• Systematic name: (8β)-N,N-Diethyl-6-propyl-9,10-didehydroergoline-8-carboxamide

Class Membership

• Psychoactive class: Psychedelic
• Chemical class: Lysergamide

Dosage

• Threshold: 20 µg
• Light: 50 - 100 µg
• Common: 100 - 200 µg
• Strong: 200 - 350 µg
• Heavy: 350 µg +

Duration

• Total: 6 - 8 hours
• Onset: 30 - 45 minutes

PRO-LAD 200mcg Blotters is for research use only and not intended for human consumption!

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PRO-LAD 200mcg Blotters stock last updated at: April 2025