Ro5-4864 1mg Blotters

Ro5-4864, also known as 4'-chlorodiazepam, is a unique benzodiazepine derivative of diazepam. Unlike most benzodiazepine derivatives, Ro5-4864 does not exhibit affinity for GABAA receptors and consequently lacks the typical effects associated with benzodiazepines. Instead, it is characterized by sedative properties, while also displaying convulsant and anxiogenic effects. This compound has been identified as a potent ligand for the peripheral benzodiazepine receptor, which has since been renamed the mitochondrial translocator protein 18kDa (TSPO). Despite its convulsant nature, Ro5-4864 has demonstrated neuroprotective effects at lower doses and has gained prominence in research focused on the role of TSPO in neurotoxicity.

Pharmacological Properties

In vitro studies and rodent models have suggested that Ro5-4864 may possess a range of additional effects, including analgesic, antidepressant, cardioprotective, and anti-cancer properties. These findings highlight the compound's potential therapeutic applications beyond its sedative effects, making it a subject of interest in various fields of biomedical research.

Chemical Information

The IUPAC name for Ro5-4864 is 7-Chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one, with a CAS number of 14439-61-3. Its molecular formula is C16H12Cl2N2O, and it has a molar mass of 319.19 g·mol−1. The compound can be identified through various chemical databases, including PubChem (CID: 1688) and ChemSpider (ID: 1625).

Ro5-4864 1mg Blotters is for research use only and not intended for human consumption!

Ro5-4864 1mg Blotters stock last updated at: April 2025